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  • 3-O-(2'E,4'Z-癸二烯酰基)巨大戟二萜醇

    3-O-(2'E,4'Z-Decadienoyl)ingenol

    3-O-(2'E,4'Z-癸二烯酰基)巨大戟二萜醇
    产品编号 CFN92867
    CAS编号 84680-59-1
    分子式 = 分子量 C30H42O6 = 498.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Diterpenoids
    植物来源 The roots of Euphorbia kansui T. N. Liou ex S. B. Ho
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    3-O-(2'E,4'Z-癸二烯酰基)巨大戟二萜醇 CFN92867 84680-59-1 1mg QQ客服:2056216494
    3-O-(2'E,4'Z-癸二烯酰基)巨大戟二萜醇 CFN92867 84680-59-1 5mg QQ客服:2056216494
    3-O-(2'E,4'Z-癸二烯酰基)巨大戟二萜醇 CFN92867 84680-59-1 10mg QQ客服:2056216494
    3-O-(2'E,4'Z-癸二烯酰基)巨大戟二萜醇 CFN92867 84680-59-1 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • Leibniz Institute of Plant Biochemistry (Germany)
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  • University of Hawaii Cancer Center (USA)
  • Chang Gung University (Taiwan)
  • University of Maryland (USA)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Heliyon2020, 6(6):e04337.
  • Journal of Ginseng Research2019, 10.1016
  • The Journal of Agromedicine and Medical Sciences2018, 4(1)
  • Microchemical Journal2024: 196:109676.
  • J Cell Physiol.2021, 236(3):1950-1966.
  • Evid Based Complement Alternat Med.2021, 8855980.
  • Int J Mol Sci.2019, 20(11):E2734
  • Evid Based Complement Alternat Med.2016, 2016:1230294
  • J Formos Med Assoc.2020, S0929-6646(20)30425-3
  • Phytomedicine.2018, 47:48-57
  • Molecules.2023, 28(7):3039.
  • J Drug Target.2016, 24:1-28
  • Br J Pharmacol.2018, 175(6):902-923
  • Front Pharmacol.2019, 10:1355
  • Front Endocrinol (Lausanne).2020, 11:568436.
  • Forensic Sci Int.2022, 341:111475.
  • The Korea Society of Pha.2014, 300-314
  • Regul Toxicol Pharmacol.2023, 142:105433.
  • Yakugaku Zasshi.2018, 138(4):571-579
  • Biomolecules.2021, 11(10):1537.
  • J Hepatocell Carcinoma.2022, 9:327-341.
  • Malaysian Journal of Analytical Sciences2022, 26(2):360-369.
  • Elife.2021, 10:e68058.
  • ...
  • 生物活性
    Description: Kansuiphorin C and 3-O-(2′E,4′Z-decadienoyl)-ingenol exhibit significant anticomplement activity with respective 50% inhibitory concentration values of 44.1±3.8 and 89.5±5.5 uM. 20-O-acetyl-[3-O-(2'E,4'Z)-decadienoyl]-ingenol and 3-O-(2'E,4'Z)-decadienoylingenol show the same antinematodal activity against the nematode, Bursaphelenchus xylophilus, at a minimum effective dose (MED) of 5 microg/cotton ball.
    Targets: Topoisomerase | Antifection
    In vitro:
    Cancer Sci. 2010 Feb;101(2):374-8.
    Analysis of inhibition of topoisomerase IIalpha and cancer cell proliferation by ingenolEZ.[Pubmed: 20175785]
    We previously reported that many ingenol compounds derived from Euphorbia kansui exhibit topoisomerase inhibitory activity and/or inhibitory activity of cell proliferation.
    METHODS AND RESULTS:
    The inhibitory effects of 20-O-(2'E,4'Z-decadienoyl) ingenol and 3-O-(2'E,4'Z-Decadienoyl)ingenol among these compounds on topoisomerase II activity and on the cell proliferative activity and arrest phase of the cell cycle were studied using a mouse breast cancer (MMT) cell line. Although 20-O-ingenolEZ exerted inhibitory effects on both topoisomerase II activity and cell proliferative activity, 3-O-ingenolEZ exerted inhibitory activity on neither. The 20-O-ingenolEZ-induced cell arrest of MMT-cell proliferation led to a cell cycle arrest in the G2/M phase. Topoisomerase II inhibition can be divided into the poison and catalytic inhibitor types. A checkpoint mechanism is activated when cells are treated with these topoisomerase II inhibitors.
    CONCLUSIONS:
    Poison-type inhibition occurs via induction of the DNA damage checkpoint and the catalytic-type inhibition occurs via induction of the DNA-decatenation checkpoint, suggestive of distinct checkpoint reactions. 20-O-ingenolEZ inhibited topoisomerase IIalpha activity through inhibition of ATPase, and induced DNA-decatenation checkpoint without signaling for phosphorylation of H2AX.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.0052 mL 10.0261 mL 20.0521 mL 40.1043 mL 50.1303 mL
    5 mM 0.401 mL 2.0052 mL 4.0104 mL 8.0209 mL 10.0261 mL
    10 mM 0.2005 mL 1.0026 mL 2.0052 mL 4.0104 mL 5.013 mL
    50 mM 0.0401 mL 0.2005 mL 0.401 mL 0.8021 mL 1.0026 mL
    100 mM 0.0201 mL 0.1003 mL 0.2005 mL 0.401 mL 0.5013 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Ingenol 20-palmitate; Ingenol 20-palmitate CFN89401 39071-33-5 C36H58O6 = 586.84 5mg QQ客服:1413575084
    13-O-正十二烷酸巨大戟酯; 13-Oxyingenol dodecanoat CFN93244 54706-70-6 C32H50O7 = 546.74 5mg QQ客服:3257982914
    12-O-十四烷酰佛波醋酸酯-13; 12-O-tetradecanoylphorbol-13-acetate CFN90367 16561-29-8 C36H56O8 = 616.83 10mg QQ客服:3257982914
    Euphohelioscopin A; Euphohelioscopin A CFN96233 87064-61-7 C30H42O6 = 498.7 5mg QQ客服:1413575084
    Lathyranoic acid A; Lathyranoic acid A CFN95325 850560-44-0 C29H34O7 = 494.6 5mg QQ客服:1413575084
    3-O-(2'E,4'Z-癸二烯酰基)巨大戟二萜醇; 3-O-(2'E,4'Z-Decadienoyl)ingenol CFN92867 84680-59-1 C30H42O6 = 498.7 5mg QQ客服:1457312923
    3-O-(2'E,4'Z-癸二烯酰基)-20-O-乙酰巨大戟二萜醇; 3-O-(2'E ,4'Z-decadienoyl)-20-O-acetylingenol CFN92864 158850-76-1 C32H44O7 = 540.7 5mg QQ客服:1413575084
    3-O-(2'E,4'E-癸二烯酰基)巨大戟二萜醇; 3-O-(2'E,4'E-Decadienoyl)ingenol CFN92868 466663-11-6 C30H42O6 = 498.7 5mg QQ客服:215959384
    3-O-(2'E,4'E-癸二烯酰基)-20-O-乙酰巨大戟二萜醇; 3-O-(2'E ,4'E-decadienoyl)-20-O-acetylingenol CFN92865 466663-12-7 C32H44O7 = 540.7 5mg QQ客服:1457312923
    Ingenol 3-palmitate; Ingenol 3-palmitate CFN89409 52557-26-3 C36H58O6 = 586.84 5mg QQ客服:2159513211

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