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  • 3-正丁烯基苯酞; 3-亚丁基-1(3H)-异苯并呋喃酮

    3-Butylidenephthalide

    3-正丁烯基苯酞; 3-亚丁基-1(3H)-异苯并呋喃酮
    产品编号 CFN99588
    CAS编号 551-08-6
    分子式 = 分子量 C12H12O2 = 188.22
    产品纯度 >=98%
    物理属性 Oil
    化合物类型 Miscellaneous
    植物来源 The roots of Ligusticum chuanxiong hort
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    3-正丁烯基苯酞; 3-亚丁基-1(3H)-异苯并呋喃酮 CFN99588 551-08-6 10mg QQ客服:2056216494
    3-正丁烯基苯酞; 3-亚丁基-1(3H)-异苯并呋喃酮 CFN99588 551-08-6 20mg QQ客服:2056216494
    3-正丁烯基苯酞; 3-亚丁基-1(3H)-异苯并呋喃酮 CFN99588 551-08-6 50mg QQ客服:2056216494
    3-正丁烯基苯酞; 3-亚丁基-1(3H)-异苯并呋喃酮 CFN99588 551-08-6 100mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universiti Sains Malaysia (Malaysia)
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  • Michigan State University (USA)
  • Universiti Malaysia Pahang (Malaysia)
  • University of Toronto (Canada)
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  • The Ohio State University (USA)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J of Food Quality2020, 8851285.
  • Int J Oncol.2016, 49(4):1497-504
  • J Ethnopharmacol.2017, 198:87-90
  • Br J Pharmacol.2018, 175(6):902-923
  • Biol Pharm Bull.2018, 41(11):1645-1651
  • Antioxidants (Basel).2022, 11(10):1929.
  • Industrial Food Engineering2015, 19(4):408-413
  • Toxins (Basel).2021, 13(9):593.
  • Mol Neurobiol.2021, 58(8):3665-3676.
  • Journal of Functional Foods2022, 98:105271.
  • Biochem Biophys Res Commun.2020, 522(4):1052-1058
  • Int J Mol Sci.2022, 23(21):13406.
  • Cancers (Basel).2021, 13(9):2223.
  • Front Pharmacol.2022, 13:806869.
  • Pathogens.2018, 7(3):E62
  • RSC Advances2017, 86
  • Molecules2022, 27(9):2827.
  • Int. J. Mol. Sci.2022, 23(8), 4130.
  • Pharmacognosy Journal2019, 11(2): 369-373
  • Tumour Biol.2015, 36(9):7027-34
  • J Biosci.2020, 45:46.
  • Nutrients2022, 14(14)2929
  • Appl. Sci.2022, 12(4), 2032.
  • ...
  • 生物活性
    Description: (Z)-3-butylidenephthalide has antihyperglycemic effect is due to inhibition of α-glucosidase at the intestinal level, inhibited the activity of yeast-α-glucosidase (IC(50) 2.35 mM) in a noncompetitive fashion with a K(i) of 4.86 mM. It can induce a dose-dependent antinociceptive action in the hot-plate assay, it is also effective for controlling the pain provoked by chemical irritation at the doses of 10 and 31.6 mg/kg.
    Targets: Nrf2 | TNF-α | NO | IL Receptor
    In vivo:
    J Nat Prod. 2011 Mar 25;74(3):314-20.
    (Z)-3-butylidenephthalide from Ligusticum porteri , an α-glucosidase inhibitor.[Pubmed: 20879744]
    An extract from the roots of Ligusticum porteri, orally administered to groups of normal and diabetic mice, showed significant hypoglycemic and antihyperglycemic effects.
    METHODS AND RESULTS:
    Experimental type-II DM was achieved by treating mice with streptozotocin 15 min after an injection of β-nicotinamide adenine dinucleotide. (Z)-6,6',7,3'α-diligustilide (1), (Z)-ligustilide (2),(Z)-3-Butylidenephthalide , myristicin (4), and ferulic acid (5) were isolated from the active extract. When tested In Vivo, compounds 1-3 showed antihyperglycemic activity, with 3 being the most active. (Z)-3-Butylidenephthalide (56.2 mg/kg) decreased blood glucose levels in NAD-STZ-diabetic mice after an oral sucrose load, suggesting that its antihyperglycemic effect is due to inhibition of α-glucosidase at the intestinal level. Furthermore, (Z)-3-Butylidenephthalide inhibited the activity of yeast-α-glucosidase (IC(50) 2.35 mM) in a noncompetitive fashion with a K(i) of 4.86 mM. Docking analysis predicted that 3 binds to the enzyme in a pocket close to the catalytic site, but different from that for acarbose, with a K(i) of 11.48 mM. Compounds 1 and 2 did not affect α-glucosidase In Vivo, but altered glucose absorption by a mechanism yet to be determined.
    CONCLUSIONS:
    The stimulatory effect of 5 on insulin secretion, present in high amounts in the extract, has been demonstrated in previous investigations. The present study provides scientific support of the use of L. porteri in Mexican folk medicine for the treatment of diabetes.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 5.3129 mL 26.5647 mL 53.1293 mL 106.2586 mL 132.8233 mL
    5 mM 1.0626 mL 5.3129 mL 10.6259 mL 21.2517 mL 26.5647 mL
    10 mM 0.5313 mL 2.6565 mL 5.3129 mL 10.6259 mL 13.2823 mL
    50 mM 0.1063 mL 0.5313 mL 1.0626 mL 2.1252 mL 2.6565 mL
    100 mM 0.0531 mL 0.2656 mL 0.5313 mL 1.0626 mL 1.3282 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    洋川芎内酯I; Senkyunolide I CFN99596 94596-28-8 C12H16O4 = 224.3 20mg QQ客服:3257982914
    6-Hydroxy-7-methoxydihydroligustilide; 6-Hydroxy-7-methoxydihydroligustilide CFN95289 210036-09-2 C13H18O4 = 238.3 5mg QQ客服:1413575084
    Riligustilide; Riligustilide CFN95457 89354-45-0 C24H28O4 = 380.5 5mg QQ客服:215959384
    Angelicolide; Angelicolide CFN93014 90826-58-7 C24H28O4 = 380.48 5mg QQ客服:3257982914
    欧当归内酯A; Levistilide A CFN99707 88182-33-6 C24H28O4 = 380.48 20mg QQ客服:215959384
    Tokinolide B; Tokinolide B CFN90612 112966-16-2 C24H28O4 = 380.48 10mg QQ客服:3257982914
    (Z)-毛叶醇内酯; (Z)-Lachnophyllum lactone CFN97868 81122-95-4 C10H10O2 = 162.2 5mg QQ客服:2159513211
    5-(2-己炔-1-基)二氢-2(3H)-呋喃酮; Tetrahydrolachnophyllum lactone CFN97885 56407-87-5 C10H14O2 = 166.2 5mg QQ客服:1457312923
    3-正丁烯基苯酞; 3-亚丁基-1(3H)-异苯并呋喃酮; 3-Butylidenephthalide CFN99588 551-08-6 C12H12O2 = 188.22 20mg QQ客服:2056216494
    新蛇床内酯; Neocnidilide CFN80081 4567-33-3 C12H18O2 = 194.27 20mg QQ客服:2159513211

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