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  • 3,6-二芥子酰基蔗糖

    3,6'-Disinapoyl sucrose

    3,6-二芥子酰基蔗糖
    产品编号 CFN90578
    CAS编号 139891-98-8
    分子式 = 分子量 C34H42O19 = 754.68
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenylpropanoids
    植物来源 The roots of Polygala tenuifolia.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    3,6-二芥子酰基蔗糖 CFN90578 139891-98-8 10mg QQ客服:3257982914
    3,6-二芥子酰基蔗糖 CFN90578 139891-98-8 20mg QQ客服:3257982914
    3,6-二芥子酰基蔗糖 CFN90578 139891-98-8 50mg QQ客服:3257982914
    3,6-二芥子酰基蔗糖 CFN90578 139891-98-8 100mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Liège (Belgium)
  • Michigan State University (USA)
  • Shanghai Institute of Organic Chemistry (China)
  • University of Lodz (Poland)
  • University of Auckland (New Zealand)
  • Universidad de Buenos Aires (Argentina)
  • Universidad de Ciencias y Artes de Chiapas (Mexico)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Food Sci Nutr.2019, 8(1):246-256
  • Toxicol Appl Pharmacol.2022, 434:115815.
  • Histol Histopathol.2022, 18518.
  • Pharmacognosy Journal.2020, 12(2), p232-235.
  • iScience.2020, 23(2):100849.
  • Turk J Med Sci.2023 53: 1312-1320.
  • Nat Prod Sci.2016, 22(2)
  • Molecules.2019, 24(6):E1155
  • Antioxidants (Basel).2020, 9(2):E99
  • Sci Rep.2020, 10:4495(2020)
  • Phytochemistry.2021, 181:112539.
  • Nat Prod Sci.2018, 24(3):206
  • Chin Med.2022, 17(1):66.
  • Molecules.2021, 26(18):5665.
  • Oncotarget.2017, 9(3):4161-4172
  • Biochem Biophys Res Commun.2019, 518(4):732-738
  • Molecules.2022, 27(13):4227.
  • ACS Synth Biol.2022, doi: 10.1021.
  • University of Stuttgart2021, 11682.
  • Life Sci.2022, 298:120488.
  • Front Pharmacol.2019, 10:1355
  • J Ethnopharmacol.2020, 269:113752.
  • Plants (Basel).2022, 11(16):2126.
  • ...
  • 生物活性
    Description: 3,6'-Disinapoyl sucrose has neuroprotective effect and antidepressive activity in rats, at least in part, by increasing expression of cyclic AMP response element (CRE)-binding protein (CREB) and its downstream target protein, brain-derived neurotrophic factor (BDNF). 3,6'-Disinapoyl sucrose protect neuron cells from glutamate-induced excitotoxicity include the downregulation of proapoptotic gene Bax and the upregulation of antiapoptotic gene Bcl-2.
    Targets: cAMP | ERK | PKA | PI3K | Bcl-2/Bax | MAO | SOD | BDNF
    In vitro:
    J Biomed Biotechnol. 2012;2012:1-5.
    Protection of SH-SY5Y neuronal cells from glutamate-induced apoptosis by 3,6'-disinapoyl sucrose, a bioactive compound isolated from Radix Polygala.[Pubmed: 21836813]
    The neuroprotective effects of 3,6'-Disinapoyl sucrose (DISS) from Radix Polygala against glutamate-induced SH-SY5Y neuronal cells injury were evaluated in the present study.
    METHODS AND RESULTS:
    SH-SY5Y neuronal cells were pretreated with glutamate (8 mM) for 30 min followed by cotreatment with 3,6'-Disinapoyl sucrose for 12 h. Cell viability was determined by (3,4,5-dimethylthiazol-2-yl)-2,5-diphenylte-trazolium bromide (MTT) assay, and apoptosis was confirmed by cell morphology and flow cytometry assay, evaluated with propidium iodide dye. Treatment with 3,6'-Disinapoyl sucrose (0.6, 6, and 60 μmol/L) increased cell viability dose dependently, inhibited LDH release, and attenuated apoptosis. The mechanisms by which 3,6'-Disinapoyl sucrose protected neuron cells from glutamate-induced excitotoxicity included the downregulation of proapoptotic gene Bax and the upregulation of antiapoptotic gene Bcl-2.
    CONCLUSIONS:
    The present findings indicated that 3,6'-Disinapoyl sucrose exerts neuroprotective effects against glutamate toxicity, which might be of importance and contribute to its clinical efficacy for the treatment of neurodegenerative diseases.
    Molecules . 2016 Oct 24;21(10):1402.
    Naturally Occurring Cinnamic Acid Sugar Ester Derivatives[Pubmed: 27783048]
    Abstract Cinnamic acid sugar ester derivatives (CASEDs) are a class of natural product with one or several phenylacrylic moieties linked with the non-anomeric carbon of a glycosyl skeleton part through ester bonds. Their notable anti-depressant and brains protective activities have made them a topic of great interest over the past several decades. In particular the compound 3',6-disinapoylsucrose, the index component of Yuanzhi (a well-known Traditional Chinese Medicine or TCM), presents antidepressant effects at a molecular level, and has become a hotspot of research on new lead drug compounds. Several other similar cinnamic acid sugar ester derivatives are reported in traditional medicine as compounds to calm the nerves and display anti-depression and neuroprotective activity. Interestingly, more than one third of CASEDs are distributed in the family Polygalaceae. This overview discusses the isolation of cinnamic acid sugar ester derivatives from plants, together with a systematic discussion of their distribution, chemical structures and properties and pharmacological activities, with the hope of providing references for natural product researchers and draw attention to these interesting compounds. Keywords: cinnamic acid sugar ester derivatives; pharmacological activity; phytochemistry; traditional Chinese medicine.
    In vivo:
    J Pharm Pharmacol. 2011 Jun;63(6):869-74.
    Possible mechanism of the antidepressant effect of 3,6'-disinapoyl sucrose from Polygala tenuifolia Willd.[Pubmed: 21585386]
    The present study was designed to observe the effects of 3,6'-disinapoyl sucrose (DISS), an active oligosaccharide ester component obtained from the roots of Polygala tenuifolia Willd., on behavioral and biochemical aspects of depression induced by chronic mild stress (CMS) in rats. It is the first exploration of the possible association between DISS's antidepressant-like effects and biochemical markers of depression, and involved measuring monoamine oxidase (MAO) activity, cortisol levels, superoxide dismutase (SOD) activity and malondialdehyde (MDA) levels.
    METHODS AND RESULTS:
    Rats were exposed to stressor once daily for consecutive 5 weeks. DISS and a positive control drug, fluoxetine, were administered via gastric intubation to once daily for consecutive 3 weeks from the third week. The results showed that rats subjected to CMS exhibit a reduction in sucrose intake. Conversely, brain MAO-A and MAO-B activity, plasma cortisol levels, and MDA levels were increased, while SOD activity was decreased following CMS exposures. DISS significantly inhibited MAO-A and MAO-B activity and blocked plasma elevated cortisol level, an indicator of the hypothalamic-pituitary-adrenal (HPA) axis. In addition, DISS increases SOD activity, inhibits lipid peroxidation, and lessens production of MDA.
    CONCLUSIONS:
    These results suggest that DISS may possess potent and rapid antidepressant properties, which are mediated via MAO, the HPA axis and oxidative systems. These antidepressant actions make DISS a potentially valuable drug for the treatment of depression.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.3251 mL 6.6253 mL 13.2506 mL 26.5013 mL 33.1266 mL
    5 mM 0.265 mL 1.3251 mL 2.6501 mL 5.3003 mL 6.6253 mL
    10 mM 0.1325 mL 0.6625 mL 1.3251 mL 2.6501 mL 3.3127 mL
    50 mM 0.0265 mL 0.1325 mL 0.265 mL 0.53 mL 0.6625 mL
    100 mM 0.0133 mL 0.0663 mL 0.1325 mL 0.265 mL 0.3313 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    毛蕊花糖苷; 麦角甾苷; Acteoside CFN97048 61276-17-3 C29H36O15 = 624.6 20mg QQ客服:215959384
    2'-乙酰基毛蕊花糖苷; 2'-Acetylacteoside CFN92452 94492-24-7 C31H38O16 = 666.6 20mg QQ客服:1413575084
    异麦角甾苷; Isoacteoside CFN97049 61303-13-7 C29H36O15 = 624.6 20mg QQ客服:3257982914
    紫葳新苷II; Campneoside II CFN95498 95587-86-3 C29H36O16 = 640.6 10mg QQ客服:1457312923
    beta-羟基麦角甾苷; beta-Hydroxyacteoside CFN95499 109279-13-2 C29H36O16 = 640.6 10mg QQ客服:3257982914
    beta-氧化毛蕊花糖苷; beta-Oxoacteoside CFN95667 149507-92-6 C29H34O16 = 638.6 5mg QQ客服:1413575084
    厚朴苷D; Magnoloside D CFN91910 1418309-03-1 C29H36O15 = 624.59 5mg QQ客服:2056216494
    Leucosceptoside A; Leucosceptoside A CFN89166 83529-62-8 C30H38O15 = 638.61 5mg QQ客服:2159513211
    地黄苷; Martynoside CFN97159 67884-12-2 C31H40O15 = 652.7 5mg QQ客服:3257982914
    异地黄苷; Isomartynoside CFN97525 94410-22-7 C31H40O15 = 652.7 5mg QQ客服:2159513211

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