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  • 3,4-Secolupa-4(23),20(29)-diene-3,28-dioic acid

    3,4-Secolupa-4(23),20(29)-diene-3,28-dioic acid

    3,4-Secolupa-4(23),20(29)-diene-3,28-dioic acid
    产品编号 CFN96940
    CAS编号 36138-41-7
    分子式 = 分子量 C30H46O4 = 470.69
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The leaves and twigs of Lithocarpus litseifolius.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    3,4-Secolupa-4(23),20(29)-diene-3,28-dioic acid CFN96940 36138-41-7 1mg QQ客服:1413575084
    3,4-Secolupa-4(23),20(29)-diene-3,28-dioic acid CFN96940 36138-41-7 5mg QQ客服:1413575084
    3,4-Secolupa-4(23),20(29)-diene-3,28-dioic acid CFN96940 36138-41-7 10mg QQ客服:1413575084
    3,4-Secolupa-4(23),20(29)-diene-3,28-dioic acid CFN96940 36138-41-7 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Anal Bioanal Chem.2020, 412(12):3005-3015.
  • BMC Complement Altern Med.2019, 19(1):339
  • J Agric Food Chem.2021, 69(14):4210-4222.
  • Environ Toxicol Pharmacol.2019, 66:109-115
  • Cell.2018, 172(1-2):249-261
  • Sci Rep.2019, 9:19059
  • Mol Plant Pathol.2022, 10.1111:mpp.13280.
  • Br J Pharmacol.2018, 175(6):902-923
  • J Nat Med.2018, 72(3):734-744
  • LWT2021, 138:110630.
  • Antioxidants (Basel).2020, 9(6):526.
  • J Microbiol Biotechnol.2022, 32(2):141-148.
  • Nutrients.2019, 11(6):E1380
  • Sci Rep.2021, 11(1):11936.
  • Sci Rep. 2017, 17332(7)
  • BMC Complement Altern Med.2017, 17(1):384
  • Molecules.2018, 23(9):E2121
  • Industrial Crops and Products2021, 163:113313.
  • Plants (Basel).2020, 9(11):1422.
  • J Med Food.2021, 24(2):151-160.
  • Ecol Evol.2022, 12(11):e9459.
  • Biomed Chromatogr.2022, 36(11):e5462.
  • Toxicol In Vitro.2019, 59:161-178
  • ...
  • 生物活性
    Description: 3,4-Secolupa-4(23),20(29)-diene-3,28-dioic acid exhibits potent inhibition of superoxide-anion generation with 86.9 ± 2.8% inhibition at 1 uM.
    In vitro:
    Planta Med. 2017 Jul 12.
    Bioactive Triterpenoids from the Leaves and Twigs of Lithocarpus litseifolius and L. corneus.[Pubmed: 28701018]

    METHODS AND RESULTS:
    Phytochemical investigation of the leaves and twigs of Lithocarpus litseifolius and Lithocarpus corneus resulted in the isolation of four new triterpenoids (1-4), three triterpenoids (5-7) isolated from a natural source for the first time, and six known compounds (8-13). In addition, four known triterpenoids (14-17) were isolated from L. corneus. Compound 1 is a 3,4-seco-lupane-type triterpenoid, and compounds 2-4 are lupane-type triterpenoids in different oxidation states. The structures of all isolated compounds were identified by spectroscopic methods, especially NMR and mass spectrometry data. The absolute configuration of 2 and 3 was confirmed by X-ray single crystallographic analysis. The anti-inflammatory activities of 1-17 and anti-HIV activities of 2-17 were evaluated.
    CONCLUSIONS:
    Among them, 3-epi-betulinic acid (8) showed a strong anti-HIV activity comparable to abacavir, a drug used for treating HIV/AIDS. 3,4-seco-4(23),20(29)-lupadiene-3,28-dioic acid (3,4-Secolupa-4(23),20(29)-diene-3,28-dioic acid ,5) exhibited potent inhibition of superoxide-anion generation with 86.9 ± 2.8% inhibition at 1 μM.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1245 mL 10.6227 mL 21.2454 mL 42.4908 mL 53.1135 mL
    5 mM 0.4249 mL 2.1245 mL 4.2491 mL 8.4982 mL 10.6227 mL
    10 mM 0.2125 mL 1.0623 mL 2.1245 mL 4.2491 mL 5.3114 mL
    50 mM 0.0425 mL 0.2125 mL 0.4249 mL 0.8498 mL 1.0623 mL
    100 mM 0.0212 mL 0.1062 mL 0.2125 mL 0.4249 mL 0.5311 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    1-脱羧-3-氧代茶酸; 1-Decarboxy-3-oxo-ceanothic acid CFN98072 214150-74-0 C29H44O3 = 440.7 5mg QQ客服:2159513211
    美洲茶酸; Ceanothic acid CFN98063 21302-79-4 C30H46O5 = 486.7 5mg QQ客服:215959384
    乙酸茶酸酯; Ceanothic acid acetate CFN99309 119533-63-0 C32H48O6 = 528.7 5mg QQ客服:2159513211
    3,4-Secolupa-4(23),20(29)-diene-3,28-dioic acid; 3,4-Secolupa-4(23),20(29)-diene-3,28-dioic acid CFN96940 36138-41-7 C30H46O4 = 470.69 5mg QQ客服:1413575084
    Chiisanoside; Chiisanoside CFN90571 89354-01-8 C48H74O19 = 955.10 5mg QQ客服:1413575084

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