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  • 23-表-26-脱氧黄肉楠碱

    23-epi-26-Deoxyactein

    23-表-26-脱氧黄肉楠碱
    产品编号 CFN91896
    CAS编号 264624-38-6
    分子式 = 分子量 C37H56O10 = 660.83
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The roots of Cimicifuga racemosa
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    23-表-26-脱氧黄肉楠碱 CFN91896 264624-38-6 1mg QQ客服:1457312923
    23-表-26-脱氧黄肉楠碱 CFN91896 264624-38-6 5mg QQ客服:1457312923
    23-表-26-脱氧黄肉楠碱 CFN91896 264624-38-6 10mg QQ客服:1457312923
    23-表-26-脱氧黄肉楠碱 CFN91896 264624-38-6 20mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidad de Ciencias y Artes de Chiapas (Mexico)
  • Lodz University of Technology (Poland)
  • University of Wollongong (Australia)
  • Universiti Kebangsaan Malaysia (Malaysia)
  • Kitasato University (Japan)
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • Institute of Chinese Materia Medica (China)
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  • University of South Australia (Australia)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Sci Rep.2018, 8(1):12970
  • J Ginseng Res.2022, 46(1):104-114.
  • J. Food Composition and Analysis2022, 114:104731
  • Phytomedicine.2019, 55:229-237
  • Phytomedicine.2022, 100:154036.
  • J Med Food.2022, 25(3):272-280.
  • Food Research2021, 5(1):65-71
  • Biol Pharm Bull.2021, 44(12):1891-1893.
  • Front Microbiol.2023, 14:1232039.
  • Applied Biological Chemistry 2022, 65,5(2022).
  • Industrial Crops and Products2022, 186:115298
  • Nutrients.2021, 13(12):4364.
  • National University of Pharmacy2022, 1:73-76
  • Integr Med Res.2021, 10(3):100723.
  • Pharm Biol.2021, 59(1):134-145.
  • Journal of Apicultural Research2021, 60(1).
  • FASEB J.2019, 33(8):9685-9694
  • Acta horticulturae2017, 1158:257-268
  • Food Res Int.2022, 157:111207.
  • Oncotarget.2017, 8(64):108006-108019
  • Clin Exp Pharmacol Physiol.2020, doi: 10.1111
  • Elife.2021, 10:e68058.
  • Int J Mol Sci.2018, 19(9):E2601
  • ...
  • 生物活性
    Description: 23-epi-26-Deoxyactein has anti-inflammatory activity, it inhibits nitric oxide production by reducing iNOS expression without affecting activity of the enzyme. It also has anti-cancer activity, it can inhibit growth of the MCF7 human breast cancer cells and induce cell cycle arrest at G1.
    Targets: CDK | p21 | NOS | NO | p65 | NF-kB
    In vitro:
    Breast Cancer Res Treat. 2004 Feb;83(3):221-31.
    Growth inhibitory activity of extracts and purified components of black cohosh on human breast cancer cells.[Pubmed: 14758092 ]
    The purpose of this study was to determine whether black cohosh contains constituents that inhibit the growth of human breast cancer cells, and therefore might eventually be useful in the prevention or treatment of breast cancer.
    METHODS AND RESULTS:
    Black cohosh rhizomes were extracted with methanol/water and fractionated by solvent-solvent partitioning to yield three fractions: hexane, ethyl acetate and water. The ethyl acetate fraction displayed the highest potency in two cell-based assays, growth inhibition and cell cycle analysis. This fraction inhibited growth of both the ER+ MCF7 and ER-MDA-MB-453 human breast cancer cell lines with IC50 values of about 20 and 10 micro g/ml, respectively. It also induced cell cycle arrest at G1 when tested at 30 micro g/ml and at G2/M at 60 micro g/ml in MCF7 cells. This suggests that the extract contains a mixture of components with the more active (or more abundant) causing G1 arrest and the less active causing G2/M arrest. We then examined specific components in this extract. The triterpene glycoside fraction obtained by polyamide column chromatography, and the specific triterpene glycosides actein, 23-epi-26-Deoxyactein and cimiracemoside A, inhibited growth of the MCF7 human breast cancer cells and induced cell cycle arrest at G1.
    METHODS AND RESULTS:
    The most potent compound, actein, decreased the level of cyclin D1, cdk4 and the hyperphosphorylated form of the pRb protein and increased the level of p21cip1 in MCF7 cells, changes that may contribute to the arrest in G1. Further studies are in progress to identify the mechanisms by which actein and related compounds present in black cohosh inhibit growth of human breast cancer cells.
    J Pharm Pharmacol. 2009 Aug;61(8):1089-96.
    Inhibition of inducible nitric oxide synthesis by Cimicifuga racemosa (Actaea racemosa, black cohosh) extracts in LPS-stimulated RAW 264.7 macrophages.[Pubmed: 19703353 ]
    Cimicifuga racemosa (Actaea racemosa, black cohosh) is used as an anti-inflammatory, antipyretic and analgesic remedy in traditional medicines. The present study focuses on the effects of C. racemosa root extracts on inducible nitric oxide synthase (iNOS) in lipopolysaccharide-stimulated murine macrophages (RAW 264.7).
    METHODS AND RESULTS:
    C. racemosa rhizome and phosphate-buffered saline extracts were analysed for phenolcarboxylic acids and triterpene glycosides using an HPLC photodiode array/evaporative light-scattering detector system. iNOS was characterised by measurement of iNOS protein (immunoblotting), iNOS mRNA (semiquantitative competitive RT-PCR), nitric oxide production (nitrite levels) and nuclear translocation of nuclear factor-kappaB (p65 subunit) protein. Incubation of lipopolysaccharide-stimulated macrophages with aqueous C. racemosa extracts (0-6 mg/ml) inhibited nitrite accumulation in a concentration-dependent manner. C. racemosa extracts also reduced iNOS protein expression and iNOS mRNA levels in a dose-dependent manner. C. racemosa extracts did not significantly inhibit iNOS activity and did not affect nuclear translocation of nuclear factor-kappaB (p65 subunit) protein. Incubation with the extract was associated with a concentration-dependent reduction of interferon beta and interferon regulatory factor 1 mRNA. Among the triterpene glycosides, 23-epi-26-Deoxyactein was identified as an active principle in C. racemosa extracts.
    CONCLUSIONS:
    Extracts from the roots of C. racemosa inhibit nitric oxide production by reducing iNOS expression without affecting activity of the enzyme. This might contribute to the anti-inflammatory activities of C. racemosa.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.5132 mL 7.5662 mL 15.1325 mL 30.265 mL 37.8312 mL
    5 mM 0.3026 mL 1.5132 mL 3.0265 mL 6.053 mL 7.5662 mL
    10 mM 0.1513 mL 0.7566 mL 1.5132 mL 3.0265 mL 3.7831 mL
    50 mM 0.0303 mL 0.1513 mL 0.3026 mL 0.6053 mL 0.7566 mL
    100 mM 0.0151 mL 0.0757 mL 0.1513 mL 0.3026 mL 0.3783 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    黄芪皂苷III; Astragaloside III CFN99174 84687-42-3 C41H68O14 = 784.97 20mg QQ客服:2159513211
    黄肉楠碱; Actein CFN99864 18642-44-9 C37H56O11 = 676.9 5mg QQ客服:2159513211
    升麻素苷; Cimicifugoside CFN90481 66176-93-0 C37H54O11 = 674.81 5mg QQ客服:215959384
    26-脱氧升麻苷; 26-Deoxycimicifugoside CFN90788 214146-75-5 C37H54O10 = 658.8 5mg QQ客服:215959384
    23-表-26-脱氧黄肉楠碱; 23-epi-26-Deoxyactein CFN91896 264624-38-6 C37H56O10 = 660.83 5mg QQ客服:1413575084
    土荆皮内酯B; Pseudolarolide B CFN91878 151368-43-3 C30H42O4 = 466.65 5mg QQ客服:3257982914
    升麻内酯A; Cimilactone A CFN92971 468733-06-4 C33H50O9 = 590.74 5mg QQ客服:1413575084
    21,24-环氧基环安坦-3,25-二醇; 21,24-Epoxycycloartane-3,25-diol CFN97836 125305-73-9 C30H50O3 = 458.73 5mg QQ客服:2159513211
    环黄芪醇; Cycloastragenol CFN99538 84605-18-5 C30H50O5 = 490.71 20mg QQ客服:3257982914
    黄芪甲苷IV; 黄芪皂苷Ⅳ; 黄芪甲苷; 黄芪甲甙; Astragaloside IV CFN99171 84687-43-4 C41H68O14 = 784.98 20mg QQ客服:1413575084

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