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  • 20-羟基蜕皮甾酮

    20-Hydroxyecdysone

    20-羟基蜕皮甾酮
    产品编号 CFN98873
    CAS编号 5289-74-7
    分子式 = 分子量 C27H44O7 = 480.6
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Steroids
    植物来源 The roots of Cyanotis arachnoidea C. B. Clarke.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    20-羟基蜕皮甾酮 CFN98873 5289-74-7 10mg QQ客服:1413575084
    20-羟基蜕皮甾酮 CFN98873 5289-74-7 20mg QQ客服:1413575084
    20-羟基蜕皮甾酮 CFN98873 5289-74-7 50mg QQ客服:1413575084
    20-羟基蜕皮甾酮 CFN98873 5289-74-7 100mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Sao Paulo (Brazil)
  • University of Lodz (Poland)
  • University of Vigo (Spain)
  • The Australian National University (Australia)
  • Periyar University (India)
  • Nicolaus Copernicus Uniwersity (Poland)
  • Universitas Airlangga (Indonesia)
  • University of Dicle (Turkey)
  • Universidade do Porto (Portugal)
  • Seoul National University (Korea)
  • University of Liège (Belgium)
  • Colorado State University (USA)
  • Northeast Normal University Changchun (China)
  • Universidade de Franca (Brazil)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Cell Physiol Biochem.2017, 43(4):1425-1435
  • Pharmacognosy Magazine2017, 13(52):868-874
  • J Ethnopharmacol.2022, 282:114574.
  • J Cell Biochem.2018, 119(2):2231-2239
  • Food Bioscience2023, 56:103311.
  • Int J Mol Sci.2021, 22(21):11447.
  • Molecules.2023, 28(3):958.
  • Phytochemistry Letters2021, 43:80-87.
  • J Ethnopharmacol.2017, 209:305-316
  • J Biol Chem.2014, 289(3):1723-31
  • Evid Based Complement Alternat Med.2021, 2021:5319584.
  • Int J Mol Sci.2020, 21(22):8816.
  • Pharmaceutics.2022, 14(5):945.
  • Pharmacol Rep.2022, 74(1):175-188.
  • Chem Biol Interact.2022, 368:110248.
  • Ind. J. Pharm. Edu. Res.2023; 57(3):1132-1139.
  • Evidence-based Compl.&Alternative Med.2023, 5417813
  • Journal of Ginseng Research2021, 3 June.
  • Korean J. of Food Sci. and Tech2016, 172-177
  • Korean J of Crop Science2019, 452-458
  • Fermentation2023, 9(10), 889
  • Int. J. Mol. Sci.2022, 23(8), 4130.
  • Molecules.2021, 26(19):6032.
  • ...
  • 生物活性
    Description: 20-Hydroxyecdysone (20E) is a naturally occurring ecdysteroid hormone which controls the ecdysis (moulting) and metamorphosis of arthropods. 20E could as ingredients in nutritional supplements for various sports, particularly bodybuilding; it induces autophagy and caspase activity, it slowly reduces food consumption and then indirectly induces a state of starvation resulting in the elevation of the mRNA levels of InR , IRS , PI3K110 , and PDK in the Bombyx fat body during molting and pupation, and it inhibits innate immunity in the fat body during Bombyx postembryonic development.
    Targets: Calcium Channel | PI3K | mTOR | Akt | Autophagy | PDK | Caspase | InR | IRS
    In vitro:
    Dev Biol. 1991 Aug;146(2):569-82.
    20-Hydroxyecdysone is required for, and negatively regulates, transcription of Drosophila pupal cuticle protein genes.[Pubmed: 1713868]

    METHODS AND RESULTS:
    Transcripts of ecdysone-dependent genes (EDGs) accumulate in isolated imaginal discs with 8 hr after exposure to a pulse of the steroid hormone 20-hydroxyecdysone (20-HE; 1 microgram/ml for 6 hr) but not in discs cultured in the continuous presence or absence of the hormone. Sequence analyses show that two of the EDGs are members of gene families encoding insect cuticle proteins. We conclude that a third EDG encodes a cuticle protein because the conceptual glycine-rich protein contains sequence motifs similar to those found in insect egg shell proteins and vertebrate cytokeratins and because expression of this gene is limited to tissues that deposit the pupal cuticle. Nuclear run-on assays show that the hormone-dependent expression of each of these EDGs is due to transcriptional regulation. Readdition of hormone to imaginal discs actively synthesizing the EDG messages causes rapid repression of EDG transcription.
    CONCLUSIONS:
    Thus, 20-HE acts as both a positive and a negative regulator of EDG transcription. Sequences in the promoter regions of two of the EDGs are similar to an ecdysone response element and may play a role in negative regulation.
    In vivo:
    Insect Mol Biol. 2014 Aug;23(4):407-16.
    20-hydroxyecdysone mediates non-canonical regulation of mosquito vitellogenins through alternative splicing.[Pubmed: 24720618]
    Vitellogenesis is one of the most well-studied physiological processes in mosquitoes. Expression of mosquito vitellogenin genes is classically described as being restricted to female adult reproduction.
    METHODS AND RESULTS:
    We report premature vitellogenin transcript expression in three vector mosquitoes: Culex tarsalis, Aedes aegypti and Anopheles gambiae. Vitellogenins expressed during non-reproductive stages are alternatively spliced to retain their first intron and encode premature termination codons. We show that intron retention results in transcript degradation by translation-dependent nonsense-mediated mRNA decay. This is probably an example of regulated unproductive splicing and translation (RUST), a mechanism known to regulate gene expression in numerous organisms but which has never been described in mosquitoes. We demonstrate that the hormone 20-hydroxyecdysone (20E) is responsible for regulating post-transcriptional splicing of vitellogenin. After exposure of previtellogenic fat bodies to 20E, vitellogenin expression switches from a non-productive intron-retaining transcript to a spliced protein-coding transcript. This effect is independent of factors classically known to influence transcription, such as juvenile hormone-mediated competence and amino acid signalling through the target of rapamycin pathway.
    CONCLUSIONS:
    Non-canonical regulation of vitellogenesis through RUST is a novel role for the multifunctional hormone 20E, and may have important implications for general patterns of gene regulation in mosquitoes.
    Insect Biochem Mol Biol. 2014 Feb;45:30-9.
    E93 predominantly transduces 20-hydroxyecdysone signaling to induce autophagy and caspase activity in Drosophila fat body.[Pubmed: 24316411]
    During the larval-prepupal transition in Drosophila, a balancing crosstalk occurs between autophagy and caspase activity in the remodeling fat body: the inhibition of autophagy induces caspase activity and the inhibition of caspases induces autophagy. Both autophagy and caspase activity are induced by a pulse of molting hormone (20-hydroxyecdysone, 20E) via the 20E nuclear receptor complex, EcR-USP.
    METHODS AND RESULTS:
    We here demonstrate that E93, a 20E primary-response gene encoding an HTH transcription factor, predominantly transduces 20E signaling to induce autophagy and caspase activity in the remodeling fat body. RNAi knockdown or mutation of E93 blocks autophagy and caspase activity, E93 overexpression induces them both, while E93 overexpression has a better rescuing effect on the inhibition of autophagy than caspase activity caused by EcR(DN) overexpression. At the transcriptional level, E93 not only greatly impacts the 20E-triggered transcriptional cascade, but also upregulates essential autophagy and apoptosis genes. Meanwhile, at the phosphorylational level, E93 blocks the PI3K-TORC1 signaling to initiate autophagy.
    CONCLUSIONS:
    Taken together, we conclude that autophagy and caspase activity are induced by 20E and predominantly transduced by E93 in the remodeling fat body of Drosophila.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.0807 mL 10.4037 mL 20.8073 mL 41.6146 mL 52.0183 mL
    5 mM 0.4161 mL 2.0807 mL 4.1615 mL 8.3229 mL 10.4037 mL
    10 mM 0.2081 mL 1.0404 mL 2.0807 mL 4.1615 mL 5.2018 mL
    50 mM 0.0416 mL 0.2081 mL 0.4161 mL 0.8323 mL 1.0404 mL
    100 mM 0.0208 mL 0.104 mL 0.2081 mL 0.4161 mL 0.5202 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    漏芦甾酮 B; Rhapontisterone B CFN90522 698975-64-3 C27H44O7 = 480.63 5mg QQ客服:1413575084
    20-羟基蜕皮甾酮; 20-Hydroxyecdysone CFN98873 5289-74-7 C27H44O7 = 480.6 20mg QQ客服:215959384
    水龙骨甾酮B; Polypodine B CFN89545 18069-14-2 C27H44O8 = 496.63 5mg QQ客服:3257982914
    蜕皮甾酮-20,22-单丙酮化物; Ecdysterone 20,22-monoacetonide CFN98229 22798-96-5 C30H48O7 = 520.7 5mg QQ客服:1457312923
    蜕皮甾酮2,3:20,22- 二缩丙酮; Ecdysterone 2,3:20,22-diacetonide CFN98230 22798-98-7 C33H52O7 = 560.8 5mg QQ客服:1457312923
    维生素D3; Vitamin D3 CFN90027 67-97-0 C27H44O = 384.64 20mg QQ客服:2056216494
    维生素D2; Ergocalciferol CFN90049 50-14-6 C28H44O = 396.65 20mg QQ客服:3257982914
    二氢胆固醇; Dihydrocholesterol CFN90608 80-97-7 C27H48O = 388.67 20mg QQ客服:1457312923
    胆固醇; 胆甾醇; Cholesterol CFN90040 57-88-5 C27H46O = 386.67 20mg QQ客服:3257982914
    4β-羟基胆固醇; 4-Beta-Hydroxycholesterol CFN90611 17320-10-4 C27H46O2 = 402.66 5mg QQ客服:1413575084

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