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  • 2,3,5,4-四羟基二苯乙烯葡萄糖苷

    2,3,5,4'-Tetrahydroxyl diphenylethylene-2-O-glucoside

    2,3,5,4-四羟基二苯乙烯葡萄糖苷
    产品编号 CFN99995
    CAS编号 82373-94-2
    分子式 = 分子量 C20H22O9 = 406.39
    产品纯度 >=98%
    物理属性 White powder
    化合物类型 Phenols
    植物来源 The roots of Polygonum multiflorum
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    2,3,5,4-四羟基二苯乙烯葡萄糖苷 CFN99995 82373-94-2 10mg QQ客服:1413575084
    2,3,5,4-四羟基二苯乙烯葡萄糖苷 CFN99995 82373-94-2 20mg QQ客服:1413575084
    2,3,5,4-四羟基二苯乙烯葡萄糖苷 CFN99995 82373-94-2 50mg QQ客服:1413575084
    2,3,5,4-四羟基二苯乙烯葡萄糖苷 CFN99995 82373-94-2 100mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidade Católica Portuguesa (Portugal)
  • Georgia Institute of Technology (USA)
  • Uniwersytet Medyczny w ?odzi (Poland)
  • Istanbul University (Turkey)
  • University of Vigo (Spain)
  • Melbourne University (Australia)
  • Universidad de Buenos Aires (Argentina)
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  • The Australian National University (Australia)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Am J Chin Med.2015, 30:1-22
  • Acta Pharm Sin B.2015, 5(4):323-9.
  • J Nat Prod.2015, 78(6):1339-4
  • Plant Cell,Tissue & Organ Culture2016, 127(1):115-121
  • J Ethnopharmacol.2016, 194:219-227
  • Int J Mol Med.2016, 37(2):501-8
  • J of the Korean Society of Food Science and Nutrition2016, 45(7):1017-1025
  • Preprints2017, 2017120176
  • J Ethnopharmacol.2017, 206:327-336
  • Chin. Med.J.Res. Prac.2017, 31(4)
  • Plant J.2017, 90(3):535-546
  • BMC Complement Altern Med.2018, 18(1):221
  • Exp Parasitol.2018, 194:67-78
  • Exp Neurobiol.2018, 27(3):200-209
  • Front Cell Infect Microbiol.2018, 8:292
  • Drug Invention Today2019, 12(6):1303-1306
  • Int J Mol Sci.2019, 20(8):E1855
  • Int J Mol Sci.2019, 20(9):E2244
  • Pak J Pharm Sci.2019, 32(6):2879-2885
  • Anal Biochem.2019, 569:10-15
  • Sci Rep.2019, 9(1):4646
  • Biochem Biophys Res Commun.2020, 522(1):40-46
  • J Nat Med.2020, 74(1):65-75
  • ...
  • 生物活性
    Description: 2,3,5,4'-Tetrahydroxyldiphenylethylene-2-O-glucoside(TSG) has potential to the prevention and treatment of Alzheimer's diseases, it not only prevents over-expression of α-synuclein at an early stage, but also reverses the increased expression of α-synuclein and inhibits the aggregation at the late stage of Tg mice. TSG suppresses PDGF-BB-induced PASMCs proliferation is associated with an inhibition of AKT / GSK3β signaling pathways. TGS, emodin and physcion also have the lipid regulation activity to an overall synergy.
    Targets: Akt | GSK-3 | P450 (e.g. CYP17) | HMG-CoA Reductase | LDL
    In vitro:
    J Ethnopharmacol. 2011 Oct 11;137(3):1291-9.
    Hepatoxicity of major constituents and extractions of Radix Polygoni Multiflori and Radix Polygoni Multiflori Praeparata.[Pubmed: 21840387]
    Radix Polygoni Multiflori (RPM) and Radix Polygoni Multiflori Praeparata (RPMP) were traditionally widely used as Chinese herbal medicine. However, liver adverse reactions caused by RPM or RPMP were frequently reported all around the world recent years. The aim of this study was to study the cytotoxicities of RPM, RPMP and their major constituents on human liver cell L-02 simultaneously.
    METHODS AND RESULTS:
    Multi-assays, including MTT assay, neutral red uptake (NRU) assay, LDH leakage percentage and liver enzyme secretion (AST, ALT and ALP) were used. Cytotoxicities of major chemical constituents of RPM, 2, 3, 5, 4'-tetrahydroxy-stilbene-2-O-β-D-glucoside (2,3,5,4'-Tetrahydroxyl diphenylethylene-2-O-glucoside,TSG), physcion and emodin, were tested. The cytotoxicities of water, 50% ethanol and 95% ethanol extractions of RPM and RPMP were tested. HPLC-DAD analysis was carried to reveal the content change of TSG, physcion and emodin after the processing procedure. The TD(50) of TSG, physcion and emodin in MTT assay were >10,000 μM, 2853.61 μM and 520.37 μM. In the NRU assay, the TD(50) of TSG, physcion and emodin were much smaller (1401.53 μM, 1140.00 μM, and 3.80 μM). Emodin induced much severe liver enzyme secretion than TSG and physcion. Cell proliferation and LDH leakage rate showed no difference between RPM and RPMP extractions, but ALP, AST and ALT secretions in RPMP extractions were significant lower than that of PMR groups. Water extractions of RPM and RPMP were less toxic than any other solvent in most of the assays. Positive correlation was found between the TSG/emodin ratio and MTT survival rate. The emodin/physcion ratio also showed positive correlation with the LDH leakage percentage. CONCLUSIONS: In conclusion, Radix Polygonum multiflorum and Radix Polygonum multiflorum Praeparata were not liver injure inducing in our in vitro assays. However, the processing produce of RPM could reduce its effect on both cell proliferation and enzyme secretion of liver cell. Judging from cell proliferation, integrity of cell membrane and enzyme secretion, three major chemical constituents of RPM: TSG, physcion and emodin showed no, moderate and severe cytotoxicity against human liver cell line L-02 respectively. Chemical constituents-cytotoxicity relationship investigation revealed that TSG and physcion probably had attenuating effect to emodin. The attenuating mechanisms were still under investigation.
    In vivo:
    Restor Neurol Neurosci. 2013;31(1):41-52.
    Tetrahydroxystilbene glucoside antagonizes age-related α-synuclein overexpression in the hippocampus of APP transgenic mouse model of Alzheimer's disease.[Pubmed: 23160059]
    To investigate the mRNA and protein alterations of α-synuclein in the brain of Alzheimer's disease-like mouse model at the different ages, and to evaluate the effects of 2,3,5,4'-tetrahydroxy stilbene-2-O-β-D-glucoside ( 2,3,5,4'-Tetrahydroxyl diphenylethylene-2-O-glucoside,TSG) on α-synuclein expression.
    METHODS AND RESULTS:
    TSG (120 or 240 μmol kg(-1)d(-1)) was intragastrically administered to APPV717I transgenic (Tg) mice at 4- or 10-month-old for 6 months. mRNA expression of α-synuclein increased in hippocampus in 4 month to 16 month old Tg mice compared with age-matched control. α-synuclein protein expression in hippocampus also increased in 4 month to 16 month old Tg mice significantly. Significant down-regulation of α-synuclein mRNA and protein expression in hippocampus was found after treatment of TSG for 6 months in both 10- and 16-month-old Tg mice. Production of dimer and tetramer of α-synuclein protein in Tg mice was inhibited after treatment with TSG.
    CONCLUSIONS:
    The expression and aggregation of α-synuclein was age-dependently increased in Tg mice. TSG not only prevents over-expression of α-synuclein at an early stage, but also reverses the increased expression of α-synuclein and inhibits the aggregation at the late stage of Tg mice. TSG may have potential to the prevention and treatment of Alzheimer's diseases.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.4607 mL 12.3035 mL 24.6069 mL 49.2138 mL 61.5173 mL
    5 mM 0.4921 mL 2.4607 mL 4.9214 mL 9.8428 mL 12.3035 mL
    10 mM 0.2461 mL 1.2303 mL 2.4607 mL 4.9214 mL 6.1517 mL
    50 mM 0.0492 mL 0.2461 mL 0.4921 mL 0.9843 mL 1.2303 mL
    100 mM 0.0246 mL 0.123 mL 0.2461 mL 0.4921 mL 0.6152 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Batatasin III; Batatasin III CFN92689 56684-87-8 C15H16O3 = 244.3 5mg QQ客服:2932563308
    3-甲氧基-5-[2-(2-甲氧基苯基)乙基]苯酚; Stilbostemin N CFN97863 1000676-45-8 C16H18O3 = 258.32 5mg QQ客服:1413575084
    紫檀芪; Pterostilbene CFN90397 537-42-8 C16H16O3 = 256.30 20mg QQ客服:2159513211
    3-羟基-4',5-二甲氧基二苯乙烯; 3-Hydroxy-4',5-dimethoxystilbene CFN95199 58436-29-6 C16H16O3 = 256.3 10mg QQ客服:2159513211
    白藜芦醇三甲醚; Trimethoxystilbene CFN90874 22255-22-7 C17H18O3 = 270.3 20mg QQ客服:2932563308
    3,5-二甲氧基-3'-羟基联苄; 3,5-Dimethoxy-3'-hydroxybibenzyl CFN89540 168281-05-8 C16H18O3 = 258.31 5mg QQ客服:2159513211
    脱氧茴香偶姻; Desoxyanisoin CFN90118 120-44-5 C16H16O3 = 256.30 5mg QQ客服:215959384
    Arundinin; Arundinin CFN91179 148225-38-1 C22H22O4 = 350.4 5mg QQ客服:2932563308
    乙酰白藜芦醇; Triacetylresveratrol CFN90895 42206-94-0 C20H18O6 = 354.4 20mg QQ客服:2932563308
    虎杖甙; Polydatin CFN99159 27208-80-6 C20H22O8 = 390.40 20mg QQ客服:2932563308

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