12-氧代四环香豆素A

12-Oxocalanolide A

	产品编号	CFN97812
	CAS编号	161753-49-7
	分子式 = 分子量	C₂₂H₂₄O₅ = 368.43
	产品纯度	>=98%
	物理属性	Yellow powder
	化合物类型	Coumarins
	植物来源	The herbs of Calophyllum polyanthum
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

提供自定义包装

产品名称	产品编号	CAS编号	包装	QQ客服
12-氧代四环香豆素A	CFN97812	161753-49-7	1mg	QQ客服：2056216494
12-氧代四环香豆素A	CFN97812	161753-49-7	5mg	QQ客服：2056216494
12-氧代四环香豆素A	CFN97812	161753-49-7	10mg	QQ客服：2056216494
12-氧代四环香豆素A	CFN97812	161753-49-7	20mg	QQ客服：2056216494

存储与注意事项

1. 在您收到产品后请检查产品。如无问题，请将产品存入冰霜并且样品瓶保持密封，产品可以存放长达24个月（2-8摄氏度）。

2. 只要有可能，产品溶解后，您应该在同一天应用于您的实验。但是，如果您需要提前做预实验，或者需要全部溶解，我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。通常，这些可用于长达两周。使用前，打开样品瓶前，我们建议您将产品平衡至室温至少1小时。

3. 需要更多关于溶解度，使用和处理的建议？请发送电子邮件至：service@chemfaces.com

订购流程

1. 在线订购

请联系我们QQ客服

2. 电话订购

请拨打电话：
027-84237683 或 027-84237783

3. 邮件或传真订购

发送电子邮件到: manager@chemfaces.com 或
发送传真到：027-84254680

提供订购信息

为了方便客户的订购，请需要订购ChemFaces产品的客户，在下单的时候请提供下列信息，以供我们快速为您建立发货信息。

1. 产品编号（CAS No.或产品名称）

2. 发货地址

3. 联系方法 (联系人，电话）

4. 开票抬头 (如果需要发票的客户）

5. 发票地址（发货地址与发票地址不同）

发货时间

1. 付款方式为100%预付款客户，我们将在确认收到货款后当天或1-3个工作日发货。

2. 付款方式为月结的客户，我们承诺在收到订单后当天或1-3个工作日内发货。

3. 如果客户所需要的产品，需要重新生产，我们有权告知客户，交货时间需要延期。

ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Institute of Pathophysiology Medical University of Vienna (Austria)

Florida International University (USA)

Aarhus University (Denmark)

The University of Newcastle (Australia)

Chinese University of Hong Kong (China)

Uniwersytet Gdański (Poland)

Center for protein Engineering (CIP) (Belgium)

Calcutta University (India)

Complutense University of Madrid (Spain)

Universiti Putra Malaysia(UPM) (Malaysia)

Kyung Hee University (Korea)

Universidad Veracuzana (Mexico)

Anna University (India)

Worcester Polytechnic Institute (USA)

More...

Description:

12-Oxocalanolide A is an inhibitor of HIV-1 reverse transcriptase (RT) and exhibits activity against a variety of viruse selected for resistance to other HIV-1 nonnucleoside RT inhibitors.

Targets:

HIV

In vitro:

Bioorg Med Chem Lett. 1998 Aug 18;8(16):2179-84

In vitro anti-human immunodeficiency virus (HIV) activity of the chromanone derivative, 12-oxocalanolide A, a novel NNRTI.[Pubmed: 9873509]

METHODS AND RESULTS:
The three chromanone derivatives, (+)-, (-)-, and (+/-)-12-Oxocalanolide A (2), were evaluated for in vitro antiviral activities against HIV and simian immunodeficiency virus (SIV).
CONCLUSIONS:
The compounds were determined to be inhibitors of HIV-1 reverse transcriptase (RT) and exhibited activity against a variety of viruses selected for resistance to other HIV-1 nonnucleoside RT inhibitors. They are the first reported calanolide analogues capable of inhibiting SIV.

In vivo:

J Chromatogr B Biomed Sci Appl. 2000 Jun 9;742(2):267-75.

Quantification of (+)-calanolide A, a novel and naturally occurring anti-HIV agent, by high-performance liquid chromatography in plasma from rat, dog and human.[Pubmed: 10901131]

METHODS AND RESULTS:
A HPLC method was validated for quantification of (+)-calanolide A (1), a novel anti-HIV agent, in rat, dog and human plasma. The synthetic intermediate (+/-)-12-Oxocalanolide A (2) was found to be a suitable internal standard. Compounds were extracted from plasma using a solid-phase C(18) cartridge and quantified over the assay range of 12.5 to 800 ng/ml. The method was utilized to determine (+)-calanolide A pharmacokinetics in rats, dogs and humans. This is the first report of a validated HPLC assay for determination of (+)-calanolide A concentrations in rat and dog plasma as well as human plasma obtained from clinical trials.
CONCLUSIONS:
There was no evidence of in vivo epimerization of (+)-calanolide A to its inactive epimer (+)-calanolide B (3).

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
7-羟基-3-异戊烯基香豆素; 7-Hydroxy-3-prenylcoumarin	CFN97429	86654-26-4	C₁₄H₁₄O₃ = 230.3	5mg	QQ客服：1413575084
7-羟基-6-甲氧基-3-异戊烯基香豆素; 7-Hydroxy-6-methoxy-3-prenylcoumarin	CFN98374	299159-90-3	C₁₅H₁₆O₄ = 260.3	5mg	QQ客服：2159513211
3-(1,1-Dimethylallyl)-8-hydroxy-7-methoxycoumarin; 3-(1,1-Dimethylallyl)-8-hydroxy-7-methoxycoumarin	CFN89287	61899-42-1	C₁₅H₁₆O₄ = 260.28	5mg	QQ客服：2159513211
状芸香素 ; Chalepensin	CFN89033	13164-03-9	C₁₆H₁₄O₃ = 254.28	5mg	QQ客服：1413575084
芸香内酯; Rutamarin	CFN89223	14882-94-1	C₂₁H₂₄O₅ = 356.41	5mg	QQ客服：1413575084
三叉苦甲素; Evodosin A	CFN89021	1291053-38-7	C₁₄H₁₆O₆ = 280.27	5mg	QQ客服：2056216494
12-氧代四环香豆素A; 12-Oxocalanolide A	CFN97812	161753-49-7	C₂₂H₂₄O₅ = 368.43	5mg	QQ客服：2056216494
胡桐素E; Calanolide E	CFN99466	142566-61-8	C₂₂H₂₈O₆ = 388.5	5mg	QQ客服：1413575084
7-氨基-4-甲基-3-香豆素醋酸; 7-Amino-4-methylcoumarin	CFN90420	106562-32-7	C₁₂H₁₁NO₄ = 233.22	5mg	QQ客服：1413575084

信息支持

公司简介
订购流程
付款方式
退换货政策

ChemFaces提供的产品仅用于科学研究使用，不用于诊断或治疗程序。

联系方式

电机：027-84237783
传真：027-84254680
在线QQ: 1413575084
E-Mail：manager@chemfaces.com

湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房

ChemFaces为科学家，科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产。

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.7142 mL	13.5711 mL	27.1422 mL	54.2844 mL	67.8555 mL
5 mM	0.5428 mL	2.7142 mL	5.4284 mL	10.8569 mL	13.5711 mL
10 mM	0.2714 mL	1.3571 mL	2.7142 mL	5.4284 mL	6.7855 mL
50 mM	0.0543 mL	0.2714 mL	0.5428 mL	1.0857 mL	1.3571 mL
100 mM	0.0271 mL	0.1357 mL	0.2714 mL	0.5428 mL	0.6786 mL