7-木糖甙-10-脱乙酰基紫杉醇

10-Deacetyl-7-xylosyl paclitaxel

	产品编号	CFN90837
	CAS编号	90332-63-1
	分子式 = 分子量	C₅₀H₅₇NO₁₇ = 944.0
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Diterpenoids
	植物来源	The barks of Taxus baccata
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产品名称	产品编号	CAS编号	包装	QQ客服
7-木糖甙-10-脱乙酰基紫杉醇	CFN90837	90332-63-1	10mg	QQ客服：1457312923
7-木糖甙-10-脱乙酰基紫杉醇	CFN90837	90332-63-1	20mg	QQ客服：1457312923
7-木糖甙-10-脱乙酰基紫杉醇	CFN90837	90332-63-1	50mg	QQ客服：1457312923
7-木糖甙-10-脱乙酰基紫杉醇	CFN90837	90332-63-1	100mg	QQ客服：1457312923

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Charles Sturt University (Denmark)

University of Maryland (USA)

Institute of Pathophysiology Medical University of Vienna (Austria)

University of Oslo (Norway)

University of Hull (United Kingdom)

Celltrion Chemical Research Institute (Korea)

Instituto Politécnico de Bragan?a (Portugal)

University of Hawaii Cancer Center (USA)

University of Auckland (New Zealand)

Sanford Burnham Medical Research Institute (USA)

Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)

Universit?t Basel (Switzerland)

Utrecht University (Netherlands)

University of Dicle (Turkey)

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Description:

10-Deacetyl-7-xylosyl paclitaxel has long been used in Chinese clinics to treat cancer, it may target mitochondrial permeability transition pore (mPTP).

In vitro:

Planta Med. 2010 Oct;76(14):1592-5.

Transport of a hydrophilic paclitaxel derivative, 7-xylosyl-10-deacetylpaclitaxel, by human intestinal epithelial Caco-2 cells.[Pubmed: 20414861 ]

7-Xylosyl-10-deacetylpaclitaxel(10-Deacetyl-7-xylosyl paclitaxel) is an active compound used in traditional Chinese medicine to treat cancer. However, pharmacokinetic studies yielded low plasma concentrations of 7-xylosyl-10-deacetylpaclitaxel after its oral administration in preclinical trials. Therefore, we investigated whether the observed low oral bioavailability of this compound is due to poor absorption.
METHODS AND RESULTS:
We studied the transepithelial flux of 7-xylosyl-10-deacetylpaclitaxel using the human colonic cell line Caco-2 as a model and found out that its flux (at a concentration range of 0.5-20 μM) across the Caco-2 cell layer was linear with time for up to 3 hr. The apparent maximal concentration (K (M)) of the active efflux component was 93.4 μM. Verapamil (50 μM) and tetrandrine (25 μM) significantly decreased the active transport component.
CONCLUSIONS:
These data support the conclusion that rapid passive diffusion of 7-xylosyl-10-deacetylpaclitaxel through the intestinal epithelium is partially counteracted by the action of an outwardly directed efflux pump, presumably P-glycoprotein. The relatively high apparent permeability coefficient ( P(app)) for the apical to basolateral 7-xylosyl-10-deacetylpaclitaxel transport (16.3 ± 6.3 × 10 (-6) cm/s; n = 3) suggests that the drug may still be effectively absorbed in the intestinal tract.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
10-去乙酰紫杉醇; Deacetyltaxol	CFN90687	78432-77-6	C₄₅H₄₉NO₁₃ = 811.87	20mg	QQ客服：1413575084
7-表紫杉醇; 7-Epitaxol	CFN90371	105454-04-4	C₄₇H₅₁NO₁₄ = 853.91	20mg	QQ客服：1457312923
紫杉醇; Paclitaxel	CFN97759	33069-62-4	C₄₇H₅₁NO₁₄ = 853.92	20mg	QQ客服：2056216494
7-木糖基-紫杉醇; 7-Xylosyltaxol	CFN98515	90332-66-4	C₅₂H₅₉NO₁₈ = 986.0	5mg	QQ客服：215959384
7-木糖甙-10-脱乙酰基紫杉醇; 10-Deacetyl-7-xylosyl paclitaxel	CFN90837	90332-63-1	C₅₀H₅₇NO₁₇ = 944.0	20mg	QQ客服：1457312923
7-表-10-去乙酰紫杉醇; 7-Epi-10-deacetyltaxol	CFN89397	78454-17-8	C₄₅H₄₉NO₁₃ = 811.86	20mg	QQ客服：1457312923
7-Epi-10-deacetylcephalomannine ; 7-Epi-10-deacetylcephalomannine	CFN89395	78479-12-6	C₄₃H₅₁NO₁₃ = 789.86	5mg	QQ客服：215959384
10-去乙酰三尖杉宁碱; 10-Deacetylcephalomannine	CFN95519	76429-85-1	C₄₃H₅₁NO₁₃ = 789.9	10mg	QQ客服：1457312923
7-木糖基-10-去乙酰基紫杉醇 B; 7-Xylosyl-10-deacetyltaxol B	CFN89389	90332-64-2	C₄₈H₅₉NO₁₇ = 921.97	20mg	QQ客服：1413575084
7-Xylosyltaxol B; 7-Xylosyltaxol B	CFN89398	90352-19-5	C₅₀H₆₁NO₁₈ = 964.01	5mg	QQ客服：215959384

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.0593 mL	5.2966 mL	10.5932 mL	21.1864 mL	26.4831 mL
5 mM	0.2119 mL	1.0593 mL	2.1186 mL	4.2373 mL	5.2966 mL
10 mM	0.1059 mL	0.5297 mL	1.0593 mL	2.1186 mL	2.6483 mL
50 mM	0.0212 mL	0.1059 mL	0.2119 mL	0.4237 mL	0.5297 mL
100 mM	0.0106 mL	0.053 mL	0.1059 mL	0.2119 mL	0.2648 mL